Thermo Fisher Scientific Phospho-DAPK1 (Ser308) Polyclonal Antibody
DAPK1 단백질의 Ser308 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. 고순도 액상 형태로 제공되며, 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-DAPK1 (Ser308) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DAPK1 (Accession P53355), corresponding to amino acid residues around phosphorylated Ser308 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817187 |
Product Specific Information
Antibody detects endogenous levels of DAPK1 only when phosphorylated at Ser308.
Target Information
DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon induced programmed cell death and is a potential tumor suppressor.
It participates in multiple cellular signaling pathways that regulate cell survival, apoptosis, and autophagy.
DAPK1 controls both type I apoptotic (caspase-dependent) and type II autophagic (caspase-independent) cell death depending on cellular context.
It phosphorylates PIN1, inhibiting its catalytic activity and nuclear localization, and also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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