Thermo Fisher Scientific CD3e Monoclonal Antibody (UCHT1), Alexa Fluor 405

Applications

• Flow Cytometry (Flow): Assay-Dependent
• View 2 publications

Product Specifications

Additional Formats

• Alexa Fluor 647
• Alexa Fluor 700
• APC
• FITC
• Pacific Blue
• Pacific Orange
• PE
• Qdot 605
• Request custom conjugation available

Target Information

The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of CD3 gamma, delta, epsilon, and zeta subunits. These subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.

CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules, mediated by a double tyrosine-based motif. CD3 may play a role in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is present on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum. It is not expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Genes encoding the CD3 epsilon, gamma, and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

Analyte Specific Reagent

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