Thermo Fisher Scientific Activin A Polyclonal Antibody
Activin A 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간에 반응하며, 다양한 종에서 예측 반응성 확인됨. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 362–426 of Inhibin beta A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.66 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_11153440 |
Product Specific Information
- Recommended positive controls: A549, H1299, HCT-116
- Predicted reactivity: Mouse (100%), Rat (100%), Cat (100%), Pig (100%), Rabbit (100%), Chicken (100%), Sheep (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins.
They signal through a heteromeric complex of receptor serine kinases, including two type I (I and IB) and two type II (II and IIB) receptors.
These receptors are transmembrane proteins with extracellular, transmembrane, and cytoplasmic domains.
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors.
After ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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