Thermo Fisher Scientific Human ARC Synthetic Peptide
Human ARC 단백질의 카르복시 말단 14개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-20305의 블로킹 펩타이드로 사용 가능하며, 인간 ARC/NOL3 단백질 연구에 적합합니다. 액상 형태, 200 µg/mL 농도, PBS(pH 7.2) 버퍼에 0.1% BSA 및 0.02% sodium azide 포함.
- 카탈로그번호
- PEP0399
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human ARC Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human Nop30.
PEP-0399 can be used as a blocking peptide with polyclonal antibody PA5-20305.
Target Information
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms. Isoform 1 is involved in RNA splicing, while isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.
ARC inhibits extrinsic apoptotic pathways by:
- Interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
- Interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting soluble CASP8 available for DISC-mediated activation.
ARC also inhibits intrinsic apoptotic pathways through interactions with BAX, resulting in BAX inactivation and prevention of mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting the gene can result in myoclonus, familial cortical disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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