Thermo Fisher Scientific MSK1 Polyclonal Antibody
MSK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 IHC(P) 등 다양한 응용에 적합. 고순도(>95%) 항원 친화 크로마토그래피 정제. 인간 및 마우스 반응성. 연구용으로만 사용.
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Thermo Fisher Scientific MSK1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 181–230 of human MSK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553588 |
Product Specific Information
- Detects endogenous MSK1 protein at approximately 90 kDa.
- Purity >95% by SDS-PAGE.
Target Information
RPS6KA5 (MSK1) is a serine/threonine protein kinase essential for regulating various cellular processes. It mediates mitogen- or stress-induced phosphorylation of transcription factors such as CREB1, ATF1, RELA, STAT3, and ETV1/ER81. MSK1 contributes to gene activation via histone phosphorylation and regulates inflammatory gene expression. It plays a key role in controlling RELA transcriptional activity in response to TNF and glucocorticoid signaling, associates with NR3C1 in the cytoplasm, and represses inflammatory gene expression. In skeletal myoblasts, it is required for RELA phosphorylation at Ser-276 during oxidative stress, and in erythropoietin-stimulated cells, it mediates Ser-727 phosphorylation of STAT3 for transcriptional regulation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-36563_MSK1_O75582-1_Rabbit.svg, PA5-36563_MSK1_O75582-1_Rabbit_PDP.jpeg)
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