Thermo Fisher Scientific 4-1BB Ligand Polyclonal Antibody
Human, Mouse, Rat 반응성을 가지는 Rabbit Polyclonal Antibody로, Western Blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%) 보유. CD137L 단백질 연구용으로 적합하며 세포 활성 및 면역 반응 연구에 활용 가능.
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Thermo Fisher Scientific 4-1BB Ligand Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 50–100 of Human 4-1BBL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803173 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily.
It acts as a co-stimulatory molecule expressed on antigen-presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation.
Its receptor, CD137/4-1BB, is found on various cells, including inflamed endothelial cells, where its expression enhances monocyte extravasation.
Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is expressed on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell lymphoma), but not on Hodgkin or T-cell lymphomas.
It is also found in carcinoma cell lines and is thought to be involved in T cell–tumor cell interactions.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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