Thermo Fisher Scientific A2M Monoclonal Antibody (9A3)
인간 혈장 유래 Alpha 2-Macroglobulin을 인식하는 Mouse IgG2b 단일클론 항체. Western blot, ELISA, Immunoprecipitation에 적합. 비결합형 액상 형태로 제공되며 -20°C 보관 필요. 알츠하이머병 관련 연구에 유용.
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Thermo Fisher Scientific A2M Monoclonal Antibody (9A3)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 1 µg |
Product Specifications
| Specification | Detail |
|---|---|
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9A3 |
| Immunogen | Alpha 2-Macroglobulin purified from human plasma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1070331 |
Product Specific Information
A suggested positive control for this product is human plasma.
Target Information
Alpha 2-Macroglobulin (A2M) is an approximately 720-kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits.
A2M shares structural and functional similarities with other alpha-macroglobulins such as complement components C3, C4, and pregnancy zone protein (PZP).
It exhibits an extraordinary binding capacity for diverse ligands, enabling alpha-macroglobulins to act as humoral defense barriers against foreign peptides in plasma.
A2M interacts and captures virtually any proteinase, functioning as a panprotease inhibitor.
In Alzheimer’s disease (AD) brains, A2M has been localized to diffuse amyloid plaques, supporting its role in AD etiopathology.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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