Thermo Fisher Scientific GBA Monoclonal Antibody (OTI1D8), TrueMAB
인간 GBA 단백질(아미노산 40–315)에 특이적인 마우스 모노클로날 항체. Western blot 및 IHC(Paraffin) 응용 가능. 무보존제, 동결건조 형태로 제공되며 재구성 및 결합 실험에 적합. Gaucher 병 관련 연구용.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 40–315 of human GBA produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
GBA encodes a lysosomal membrane enzyme that cleaves the beta-glucosidic linkage of glycosylceramide, a key intermediate in glycolipid metabolism.
Mutations in this gene cause Gaucher disease, a lysosomal storage disorder characterized by accumulation of glucocerebrosides.
A related pseudogene lies approximately 12 kb downstream on chromosome 1.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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