Thermo Fisher Scientific cGAS Monoclonal Antibody (HGAYN), eBioscience
인간 cGAS 단백질을 인식하는 HGAYN 단클론 항체입니다. Western blot 및 면역세포염색에 사용됩니다. 단백질 G로 정제된 액상 항체로, 0.5 mg/mL 농도이며 PBS(pH 7.2)에 0.09% sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HGAYN |
| Immunogen | E. coli-derived recombinant human cGAS protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2762638 |
Product Specific Information
This HGAYN monoclonal antibody recognizes human cGAS and is suitable for use on reduced lysates.
- Applications Reported: Western Blot analysis
- Applications Tested: Tested by Western Blot using HeLa cell lysates, recommended ≤ 2 µg/mL
Target Information
cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP, playing a crucial role in innate immunity.
Catalysis involves both the formation of 2’,5’ phosphodiester linkage at the GpA step and 3’,5’ linkage at the ApG step, producing c[G(2’,5’)pA(3’,5’)p].
cGAS binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, which in turn activates TMEM173/STING and triggers type-I interferon production.
It is also involved in DNA sensing during infection, stress response, DNA damage detection, and regulation of cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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