Thermo Fisher Scientific Human SPRED1 Synthetic Peptide
인간 Spred1 단백질의 중심부 20개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. 항체 PA5-20617의 블로킹 펩타이드로 사용 가능합니다. Ras-MAPK 신호전달 연구 및 종양 억제 관련 기전 연구에 적합합니다. 연구용 전용 시약입니다.
- 카탈로그번호
- PEP0737
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 20 amino acids near the center of human Spred1.
PEP-0737 can be used as a blocking peptide with polyclonal antibody PA5-20617.
Target Information
The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf.
Spred proteins are also involved in negative feedback regulation of FGF signaling during embryogenesis and angiogenesis.
Expression levels of Spred1 and Spred2 are inversely correlated with tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting potential roles as prognostic factors and therapeutic targets in HCC.
Defects in this gene are associated with neurofibromatosis type 1-like syndrome (NFLS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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