Thermo Fisher Scientific Human HINT1 Synthetic Peptide

Thermo Fisher Scientific Human HINT1 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the center of human HINT1.
PEP-0733 can be used as a blocking peptide with polyclonal antibody PA5-20613.

Target Information

Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins.
HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. It catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression.
Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, which may contribute to its tumor suppressor activity. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.