Thermo Fisher Scientific Human SPRED1 Synthetic Peptide
인간 Spred1 중심부의 14개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. PA5-20618 항체의 블로킹 펩타이드로 사용 가능하며, Ras-MAP kinase 경로 연구에 적합합니다. 정제된 액상 형태로 PBS 버퍼에 보존되며 연구용으로만 사용됩니다.
- 판매단위
- pk
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Thermo Fisher Scientific Human SPRED1 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the center of human Spred1.
PEP-0738 can be used as a blocking peptide with polyclonal antibody PA5-20618.
Target Information
The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf.
The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis.
Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC.
Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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