Thermo Fisher Scientific PGC1 alpha Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

View 13 publications 13 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Published species

Horse, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant 19 amino acid peptide near the carboxy terminus of human PGC-1 alpha, located within the last 50 amino acids if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PPARGC1A,uniProtId:Q9UBK2-1,ncbiNodeId:9606,antigenRange:749-798,antigenLength:798,antigenImageFileName:PA5-38021_PPARGC1A_Q9UBK2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-38021_PPARGC1A_Q9UBK2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Wet ice

RRID

AB_2554625

Product Specific Information

At least three isoforms of PPARGC1A are known to exist; this antibody only detects the longest isoform. PA5-38021 is predicted to react with pig and bovine based on 100% sequence homology.

Recommended positive controls: Human liver tissue/lysate, mouse liver tissue.

Target Information

PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it`s interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.