Thermo Fisher Scientific IQSEC1 Polyclonal Antibody
IQSEC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ICC/IF에 적합하며, 인간·생쥐·랫드 반응성. 액상 형태, 항원 친화 크로마토그래피로 정제. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 19 amino acid peptide near the amino terminus of human IQSEC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2554623 |
Product Specific Information
- Recommended positive control: A-20 cell lysate
- At least four isoforms of IQSEC1 are known to exist.
- IQSEC1 antibody is not expected to cross-react with IQSEC2.
Target Information
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation.
IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain, and one SEC7 domain.
As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin, and its knockdown blocked tumor metastasis.
IQSEC1 links EGFR signaling to ARF6 activation and may contribute to cancer metastasis and malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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