Thermo Fisher Scientific LRRC8C Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human LRRC8C

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643556

Product Specific Information

Immunogen sequence: LERLSFSHNK IEVLPSHLFL CNKIRYLDLS YNDIRFIPPE IGVLQSLQYF SITCNKVESL PDELYFCKKL KTLKIGKNSL SVLSPKIGNL LFLSYLDVKG NHFEILPPEL GDCRALKRAG LVVEDALFET L

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

Target Information

LRRC8C is a protein coding gene. Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.