Thermo Fisher Scientific CD4 Monoclonal Antibody (OTI1D6), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The CD4 antigen participates in the recognition of MHC class II molecules and serves as a co-receptor for HIV. CD4 is mainly expressed in T helper cells but can also be found in monocytes, macrophages, and dendritic cells.
Tissue-level expression includes thymus, lymph nodes, tonsils, spleen, and certain regions of the brain and gut.
CD4 contributes to early T-cell activation through interactions with the T-cell receptor complex and protein tyrosine kinase Lck.
It may also play a role in neuronal damage in infectious and immune-mediated CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.