Thermo Fisher Scientific IFNAR1 Polyclonal Antibody
인간 IFNAR1을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC(P) 및 ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태, 0.1 mg/mL 농도, PBS와 글리세롤 버퍼 포함. 연구용 전용 시약으로 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific IFNAR1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IFNAR1 (Product #RP-90976) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789769 |
Product Specific Information
Immunogen sequence:
KWKQIPDCEN VKTTQCVFPQ NVFQKGIYLL RVQASDGNNT SFWSEEIKFD TEIQAFLLPP VFNIRSLSDS FHIYIGAPKQ SGNTPVIQDY PLIYEIIFWE NTSNAERKII EKKTDVTVPN LKPLTVYCVK ARAHTMDEKL N
Target Information
Interferons are widely used therapeutic agents because of their antitumor and antiviral effects and their modulatory effects on the immune system (Biron, 2001; Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Downregulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This downregulation is thought to be influenced by phosphorylation of Serine 535 and 539 in IFNAR1 (Kumar et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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