Thermo Fisher Scientific HIP1 Polyclonal Antibody
Human HIP1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 0.3 mg/mL 농도의 액상 형태로 제공됩니다. HIP1 관련 신경퇴행성 질환 및 암 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HIP1 (Product # RP-90750) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789766 |
Product Specific Information
Immunogen sequence:
QVIQDALNQL EEPPLISCAG SADHLLSTVT SISSCIEQLE KSWSQYLACP EDISGLLHSI TLLAHLTSDA IAHGATTCLR APPEPADSLT EACKQYGRET LAYLASLEEE GSLENADSTA MRNCLSKIKA IGEELLPRGL
Target Information
Huntingtin disease, a neurodegenerative disorder, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntington’s disease.
HIP-1 also plays a role in the recruitment of clathrin coats to lipid membranes and may contribute to tumorigenesis by supporting the survival of precancerous and cancerous cells.
Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a potential prognostic factor for these cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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