Thermo Fisher Scientific Phospho-Cyclin B1 (Ser128) Polyclonal Antibody
Cyclin B1의 Ser128 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, 세포주기 조절 연구에 적합합니다. Western blot 및 Immunocytochemistry에 최적화된 희석 범위를 제공합니다. 고순도 액상 형태로 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Cyclin B1 around the phosphorylation site of Ser128. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817389 |
Target Information
Cyclins bind to and regulate the activity of Cyclin-dependent protein kinases (CDKs). Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis and is essential for controlling the cell cycle at the G2/M transition. It forms a maturation-promoting factor (MPF) complex with p34 (cdc2). Two alternative transcripts exist: one constitutively expressed and another regulated during the G2/M phase. Cyclin B1 accumulates during G2 phase and is degraded at the end of mitosis via APC-dependent destruction. Overexpression of Cyclin B1 has been observed in various cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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