Thermo Fisher Scientific FOXP3 Monoclonal Antibody (450)
Human FOXP3 단백질을 표적하는 Mouse IgG3 단클론 항체로, WB, IHC(P), IHC(F) 등 다양한 응용에 적합. 단백질 A로 정제된 액상 형태이며, 1 mg/mL 농도. 면역조절 관련 연구용으로 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 450 |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 400 to the C-terminus of Human FOXP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 6.97% arginine |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10989334 |
Product Specific Information
MA5-14662 targets FOXP3 in IF, IHC (P), IP, and WB applications and shows reactivity with Human samples.
The MA5-14662 immunogen is a synthetic peptide derived from residues 400 to the C-terminus of Human FOXP3.
MA5-14662 detects FOXP3 which has a predicted molecular weight of approximately 48 kDa.
Target Information
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis.
FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25+ CD4+ regulatory T cells, at a low level in CD4+/CD25− cells, and absent in CD4−/CD8+ T cells.
FOXP3 may act as a master regulatory gene and a specific marker of regulatory T cells.
Defects in FOXP3 cause the scurfy phenotype in mice and are associated with IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome) in humans.
Transcript variants encoding different isoforms have been identified. In human breast and colon cancer cells, FOXP3 expression is regulated by p53 in response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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