Thermo Fisher Scientific CDK2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Positive test controls include: 293T, HeLa.
The target is usually found in the following locations: Cajal body, Cytoplasm, Endosome, Nucleus, Centrosome, Cytoskeleton, Microtubule organizing center.

Immunogen sequence:
RALFPGDSEI DQLFRIFRTL GTPDEVVWPG VTSMPDYKPS FPKWARQDFS KVVPPLDEDG RSLLSQMLHY DPNKRISAKA ALAHPFFQDV TKPVPHLRL

Target Information

CDK2/cyclinO is a member of the cyclin-dependent protein kinase family, complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene localized exclusively in the nucleus. CyclinO shows significant uracil-DNA glycosylase activity.
CDK2/cyclinO protein levels increase during G1 phase and are turned over during the cell cycle. Cyclin A–CDK2 levels are maximal at the G1/S transition, and both CDK2 and cyclin A are associated with DNA in the initiation complex during replication.
Rb protein acts as a substrate for CDK2–cyclin E and/or CDK2–cyclin A in vivo. CDK2 is activated and localized to the nucleus during late G1, S, and G2 phases.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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