Thermo Fisher Scientific CDK2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CDK2 for WB, IHC, and ELISA applications. High specificity with affinity-purified formulation. Supplied as liquid in PBS/glycerol buffer. For research use only.
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- PA5120042
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 200–298 of human CDK2 (NP_001789.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.47 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913614 |
Product Specific Information
Positive test controls include: 293T, HeLa.
The target is usually found in the following locations: Cajal body, Cytoplasm, Endosome, Nucleus, Centrosome, Cytoskeleton, Microtubule organizing center.
Immunogen sequence:
RALFPGDSEI DQLFRIFRTL GTPDEVVWPG VTSMPDYKPS FPKWARQDFS KVVPPLDEDG RSLLSQMLHY DPNKRISAKA ALAHPFFQDV TKPVPHLRL
Target Information
CDK2/cyclinO is a member of the cyclin-dependent protein kinase family, complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene localized exclusively in the nucleus. CyclinO shows significant uracil-DNA glycosylase activity.
CDK2/cyclinO protein levels increase during G1 phase and are turned over during the cell cycle. Cyclin A–CDK2 levels are maximal at the G1/S transition, and both CDK2 and cyclin A are associated with DNA in the initiation complex during replication.
Rb protein acts as a substrate for CDK2–cyclin E and/or CDK2–cyclin A in vivo. CDK2 is activated and localized to the nucleus during late G1, S, and G2 phases.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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