Thermo Fisher Scientific SFPQ Polyclonal Antibody
SFPQ 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ICC, ELISA, IP 등 다양한 응용에 적합하며, 액상 형태로 제공됩니다. Affinity Chromatography로 정제되어 높은 특이성과 재현성을 보장합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 200 µg–400 µg extracts |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 578–707 of human SFPQ (NP_0050571) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.21 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804230 |
Product Specific Information
Immunogen sequence:
MMIRQREMEE QMRRQREESY SRMGYMDPRE RDMRMGGGGA MNMGDPYGSG GQKFPPLGGG GGIGYEANPG VPPATMSGSM MGSDMRTERF GQGGAGPVGG QGPRGMGPGT PAGYGRGREE YEGPNKKPRFPositive Samples:
OVCAR3, HeLa, Jurkat, HepG2, Mouse brain, Mouse liver, Mouse spleen, Rat brainCellular Location:
Cytoplasm, Nucleus matrix
Target Information
SFPQ (also known as PSF) encodes a nuclear factor involved in splicing and regulation of gene expression. SFPQ forms a heteromer with NONO and participates in DNA pairing and DNA break repair. It has been identified as a downstream target of tau, with nuclear depletion and cytoplasmic accumulation observed in neurons and astrocytes of Alzheimer’s disease brains. Reduced SFPQ levels correlate with tau pathology, suggesting its key role in neurodegenerative diseases. SFPQ protein may appear as 47 kDa, 52 kDa, or 100 kDa molecules depending on cell type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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