Thermo Fisher Scientific Caspase 1 Polyclonal Antibody
Caspase 1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. 인간 및 생쥐 반응성, 친화 크로마토그래피 정제, 액상 형태로 보관. 세포 내 염증 및 세포사 연구용으로 활용 가능.
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- PA587536
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Thermo Fisher Scientific Caspase 1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | View 4 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | View publications |
| ELISA | 1 µg/mL | View publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 201–300 of human Caspase 1 (NP_150634.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.14 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804233 |
Product Specific Information
- Positive Samples: THP-1, Mouse lung, Rat spleen
- Cellular Location: Cytoplasm
- Immunogen Sequence: CRGDSPGVVW FK
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Unlike apoptotic caspases, inflammatory caspases (including caspase-1, -4, -5, and -12) are associated with immune responses to microbial pathogens and activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β–converting enzyme and later shown to be a mammalian homolog of the C. elegans cell death gene ced-3, capable of inducing apoptosis in fibroblasts upon overexpression.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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