Thermo Fisher Scientific PAK6 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human PAK6 protein. Suitable for WB, IHC(P), and IP applications. Validated in multiple species with high predicted reactivity. Supplied as a liquid form for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 307–681 of Human PAK6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546150 |
Product Specific Information
- Recommended positive control: 293T transfected recombinant PAK6 protein
- Predicted reactivity: Mouse (97%), Rat (98%), Rhesus Monkey (99%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PAK6 is a serine/threonine kinase expressed in the testis and prostate. It associates with both the estrogen and androgen receptors.
The p21-activated kinases (PAKs) are serine/threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups:
- Group 1 (PAK1, 2, 3): Activated by Cdc42/Rac binding and contain an autoinhibitory domain. Involved in gene transcription, apoptosis, and cell morphology/motility.
- Group 2 (PAK4, 5, 6): Not activated by Cdc42/Rac binding. PAK6 can be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting a role in cellular stress responses.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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