Thermo Fisher Scientific SCN9A Polyclonal Antibody

Thermo Fisher Scientific SCN9A Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:400

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• Store reconstituted solution at 4°C for up to 1 week.
• For longer storage, aliquot and keep at -20°C.
• Avoid repeated freeze-thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Peptide sequence: (C)EFTSIGRSRIMGLSE
Homology: Human, mouse – 13/15 amino acid residues identical.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels possess two short intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region.
ENaC isoforms (α, β, γ) are expressed in kidney, lung, and colon, playing a key role in sodium and fluid balance. They mediate aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.
Association with CFTR chloride channels contributes to regulation.
Mutations in ENaC subunits can lead to disorders such as Liddle’s syndrome (gain-of-function) or pseudohypoaldosteronism type 1 (loss-of-function).

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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