Thermo Fisher Scientific KCNK2 Polyclonal Antibody
Guinea pig 유래 KCNK2 폴리클로날 항체로 TREK-1 채널 연구에 적합. WB, IHC(F), ICC/IF 등 다양한 응용 가능. 인간 KCNK2 N-말단 펩타이드 기반으로 제작된 미결합 항체. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:800 |
| Immunohistochemistry (Frozen) (IHC(F)) | 1:400 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Guinea pig / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to residues 8–25 of human KCNK2 (Intracellular, N-terminus) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2857224 |
Product Specific Information
- Reconstitute antibody with 50 µL of double distilled water (DDW).
- Store reconstituted solution at 4°C for up to 1 week.
- For longer storage, aliquot and keep at -20°C.
- Avoid multiple freeze-thaw cycles.
- Centrifuge antibody preparations before use (10,000 × g, 5 min).
Peptide sequence: DPKSAAQNSK PRLSFSTK(C)
Homology: Rat – identical amino acid residues; Mouse – 17/18 residues identical.
Target Information
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is activated by polyunsaturated fatty acids and lysophospholipids and regulated by various neurotransmitters. Alterations in TREK-1 function or regulation may influence mood. It is also activated by volatile anesthetics and considered a potential therapeutic target in anesthesiology and neurology, including antidepressant development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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