Thermo Fisher Scientific SUPT5H Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC-P)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.
• Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea pig, Pig, Panda, Orangutan, Monkey, Gorilla, and Chimpanzee.

Target Information

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. It acts cooperatively with the NELF complex to enhance transcriptional pausing at promoter-proximal sites, facilitating assembly of elongation-competent RNA polymerase II complexes. DSIF and NELF promote pausing by inhibiting TFIIS/S-II, which stimulates intrinsic nuclease activity of RNA polymerase II. DSIF can also positively regulate transcriptional elongation and is required for efficient activation by the HIV-1 Tat protein, preventing premature transcript release from the HIV-1 LTR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.