Thermo Fisher Scientific LGMN Polyclonal Antibody
LGMN 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제, 액상 형태, -20°C 보관.
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Thermo Fisher Scientific LGMN Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 26–288 of human Legumain (LGMN) (NP_005597.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.01 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804568 |
Product Specific Information
- Positive Samples: Mouse lung, Mouse liver
- Cellular Location: Lysosome
Immunogen sequence:
GGKHWVVIVA GSNGWYNYRH QADACHAYQI IHRNGIPDEQ IVVMMYDDIA YSEDNPTPGI VINRPNGTDV YQGVPKDYTG EDVTPQNFLA VLRGDAEAVK GIGSGKVLKS GPQDHVFIYF TDHGSTGILV FPNEDLHVKD LNETIHYMYK HKMYRKMVFY IEACESGSMM NHLPDNINVY ATTAANPRES SYACYYDEKR STYLGDWYSV NWMEDSDVED LTKETLHKQY HLVKSHTNTS HVMQYGNKTI STMKVMQFQG MKR
Target Information
This gene encodes a cysteine protease with strict specificity for hydrolysis of asparaginyl bonds. It is involved in processing bacterial peptides and endogenous proteins for MHC class II presentation in lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and is autocatalytic. Expression occurs after monocytes differentiate into dendritic cells, producing a mature active enzyme following lipopolysaccharide expression. Overexpression may be associated with many solid tumor types. A pseudogene exists on chromosome 13. Several alternatively spliced transcript variants have been described, with biological validity confirmed for two.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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