Thermo Fisher Scientific TWIST1 Polyclonal Antibody
TWIST1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. Western blot에 적합하며, 인간 및 설치류 등 다양한 종에서 반응. 액상 형태로 제공되며, -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human TWIST1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2691014 |
Product Specific Information
This target displays homology in the following species:
Cow: 100% | Horse: 100% | Human: 100% | Mouse: 100% | Rat: 100% | Zebrafish: 93%
Target Information
TWIST1 acts as a transcriptional regulator. It inhibits myogenesis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. Additionally, TWIST1 regulates cranial suture patterning and fusion, and gene expression varies depending on dimer composition.
Mutations in this gene are implicated in Saethre-Chotzen syndrome, characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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