Thermo Fisher Scientific Phospho-AHNAK (Ser5782) Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

Phospho-AHNAK (Ser5782) Polyclonal Antibody detects endogenous levels of AHNAK only when phosphorylated at Ser5782.

Target Information

AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increase in extracellular calcium level or upon protein kinase C activation, and regulates extracellular calcium influx mediated by L-type Ca²⁺ channels.
AHNAK1 is involved in signal transduction processes affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts, AHNAK1 forms multimeric complexes in the plasma membrane, associated with actin and annexin 2/S100A10 assemblies, contributing to membrane architecture organization.
In epithelial cells, AHNAK1 is cytoplasmic or membrane-associated, while in nonepithelial cells it is predominantly nuclear, showing weak DNA-binding activity and association with the DNA-ligase IV-XRCC4 complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.