Thermo Fisher Scientific TIM17 Polyclonal Antibody
TIM17 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. 인간과 마우스에 반응하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 108–171 of TIM17 (Uniprot ID: Q99595) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_11152383 |
Product Specific Information
- Recommended positive controls: A431, H1299, HeLa
- Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Translocation of nuclear encoded preproteins into the mitochondrial matrix requires the coordinated action of the translocases Tom and Tim, located in the outer and inner mitochondrial membranes respectively.
The Tom complex includes multiple subunits such as Tom70, Tom37, Tom22, and Tom20, which function as import receptors, and small structural proteins (Tom7, Tom6, Tom5) forming the import pore (GIP).
The TIM channel imports nuclear-encoded mitochondrial preproteins through Tim17, Tim23, and Tim44, present at equimolar ratios.
Tim17 exists as two isoforms (Tim17a and Tim17b), differing in their C-terminal sequences, and both are ubiquitously expressed. Tim17 and Tim23 form the structural components of the inner membrane channel, while Tim44 recruits matrix Hsp70 to assist preprotein translocation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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