Thermo Fisher Scientific P2X2 Polyclonal Antibody
P2X2 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 인간 및 생쥐 반응성 보유. 고순도 Affinity chromatography 정제, -20°C 보관.
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Thermo Fisher Scientific P2X2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human P2RX2 (Accession Q9UBL9), amino acid residues H408–Q458 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900341 |
Product Specific Information
Antibody detects endogenous levels of total P2X2.
Target Information
P2rx2 belongs to the ligand-gated ion channel family that opens in response to extracellular ATP. Each receptor consists of a trimer of subunits (P2X1–7), all sharing two transmembrane domains. P2rx2 mediates synaptic transmission between neurons and from neurons to smooth muscle.
Six transcript variants encoding distinct isoforms have been identified. P2rx2 is involved in various cellular responses, including excitatory postsynaptic signaling, neuromuscular junction formation, hearing, taste perception, and peristalsis.
In the inner ear, P2rx2 regulates sound transduction, auditory neurotransmission, outer hair cell electromotility, gap junctions, and K⁺ recycling.
Diseases associated with P2RX2 include Deafness, Autosomal Dominant 41, and DFNA41 Nonsyndromic Hearing Loss and Deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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