Thermo Fisher Scientific MYOC Polyclonal Antibody
MYOC 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 적합. 인간 MYOC N-말단 펩타이드(aa 101-150)를 면역원으로 제작. 액상 형태, 0.5 mg/mL 농도. PBS(2% sucrose) buffer에 보관하며 -20°C에서 보존.
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- PA545027
- 판매단위
- pk
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Applications
- Western Blot (WB): 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human MYOC (aa 101-150) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2605810 |
Product Specific Information
Peptide sequence:
QLTLDQAARP QETQEGLQRE LGTLRRERDQ LETQTRELET AYSNLLRDKS
Sequence homology:
- Guinea Pig: 86%
- Human: 100%
- Rat: 79%
Target Information
Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork, and ciliary body. It can form homomultimers in vivo and associate with extracellular matrix components via interactions with the Hep II domain of FibroPVRL1. Myocilin also interacts with myosin regulatory light chain, linking it to the actomyosin system and trabecular meshwork (TM) function, which regulates intraocular pressure (IOP). Dysfunction in TM may lead to elevated IOP and glaucoma. The MYOC gene (also known as TIGR) maps to chromosome 1q24.3, and mutations in MYOC are associated with primary open-angle glaucoma (POAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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