Thermo Fisher Scientific DR3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human DR3 (TNFRSF25), validated for Western blot. Recognizes residues 398–417 of human DR3. Supplied as liquid, unconjugated form, purified by Protein G. Recommended positive control: HeLa cell lysate.
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Applications
- Western Blot (WB): Tested dilution 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 398–417 of human DR3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1074097 |
Product Specific Information
- Suggested positive control: HeLa whole cell extract, HeLa cell lysate.
Target Information
DR3 (TNFRSF25) is a member of the TNF-receptor superfamily, expressed primarily in lymphocyte-rich tissues. It plays a role in regulating lymphocyte homeostasis, stimulating NF-κB activity, and controlling apoptosis. Signal transduction is mediated by death domain-containing adaptor proteins. Knockout studies in mice suggest DR3/TNFRSF25 is involved in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants exist, many of which encode secreted isoforms. In activated T cells, alternative splicing shifts toward full-length, membrane-bound isoforms, potentially regulating lymphocyte proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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