Thermo Fisher Scientific Glutamine Synthetase/GLUL Monoclonal Antibody (GLUL/6599)
인간 GLUL 단백질을 인식하는 Mouse 모노클로날 항체로, Western blot 및 IHC에 적합. 단백질 A/G로 정제된 액상형 항체이며 4°C에서 안정적으로 보관 가능. Astrocyte 마커로 신경 및 간 연구에 활용.
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Thermo Fisher Scientific Glutamine Synthetase/GLUL Monoclonal Antibody (GLUL/6599)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GLUL/6599 |
| Immunogen | Recombinant fragment (around aa 50–250) of human GLUL protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human brain, stomach or thyroid; A-431 or Y79 cells.
- Cellular Localization: Cytoplasm, mitochondrion.
Specificity Comments:
Glutamine synthetase (GlSyn) forms a homo-octamer that catalyzes the amination of glutamic acid to form glutamine. This enzyme serves as a marker for astrocytes, the primary site for conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase occurs upon astrocyte contact with neurons. Elevated expression in glial cells protects neurons from degeneration due to excess glutamate. It is also present in the liver and involved in nitrogen homeostasis. Overexpression in primary liver cancers suggests a role in hepatocyte transformation.
Target Information
Glutamine synthetase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthetase. Glutamate plays a central role in mammalian nitrogen flow, serving as both nitrogen donor and acceptor. It also regulates neurotransmitter glutamate metabolism. GS activity and synthesis are tightly regulated, controlled by adenylylation. Activity decreases in the cerebral cortex of Alzheimer’s disease brains, particularly near senile plaques, and under glucose deprivation conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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