Thermo Fisher Scientific Glutamine Synthetase/GLUL Monoclonal Antibody (GLUL/6604)
Thermo Fisher Scientific의 Glutamine Synthetase/GLUL Monoclonal Antibody (GLUL/6604)는 인간 시료에 반응하는 Mouse IgG2b 단일클론 항체로, WB 및 IHC(P) 등에 사용 가능. 세포 내 글루타민 합성 효소 검출에 적합하며, 뇌와 간 조직 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GLUL/6604 |
| Immunogen | Recombinant fragment (around aa 50–250) of human GLUL protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human brain, stomach or thyroid; A-431 or Y79 cells.
- Cellular Localization: Cytoplasm, Mitochondrion.
Specificity Comments:
Glutamine synthetase (Gl Syn) forms a homo-octamer that catalyzes the amination of glutamic acid to form glutamine. It serves as a marker for astrocytes, which convert glutamic acid to glutamine in the brain. Induction of glutamine synthetase occurs upon astrocyte contact with neurons. Elevated expression in glial cells protects neurons from degeneration due to excess glutamate. The enzyme is also expressed in the liver and involved in nitrogen homeostasis. Overexpression has been observed in primary liver cancers, suggesting a role in hepatocyte transformation.
Target Information
Glutamine synthase belongs to the glutamine synthetase family. In animals, ammonia incorporation occurs via glutamate dehydrogenase and glutamine synthase. Glutamate plays a central role in nitrogen metabolism, acting as both a nitrogen donor and acceptor. It also regulates neurotransmitter glutamate metabolism. Both catalytic activity and synthesis of GS are tightly regulated, with activity controlled by adenylylation. GS activity is decreased in the cerebral cortex of Alzheimer’s disease brains, especially near senile plaques, and under glucose deprivation conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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