Thermo Fisher Scientific CD254 (RANK Ligand) Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Positive test controls include: K-562, SW620, A-549.
The target is usually found in the following locations: Cell membrane, Cytoplasm, Secreted, Single-pass type II membrane protein.

Immunogen sequence:
RISEDGTHCI YRILRLHENA DFQDTTLESQ DTKLIPDSCR RIKQAFQGAV QKELQHIVGS QHIRAEKAMV DGSWLDLAKR SKLEAQPFAH LTINATDIPS GSHKVSLSSW YHDRGWAKIS NMTFSNGKLI VNQDGFYYLY ANICFRHHET SGDLATEYLQ LMVYVTKTSI KIPSSHTLMK GGSTKYWSGN SEFHFYSINV GGFFKLRSGE EISIEVSNPS LLDPDQDATY FGAFKVRDID

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
This protein acts as a dendritic cell survival factor and regulates T cell-dependent immune responses.
T cell activation induces expression of this gene, leading to increased osteoclastogenesis and bone loss.
It activates antiapoptotic kinase AKT/PKB via a complex involving SRC kinase and TRAF6, suggesting a role in cell apoptosis regulation.
Gene disruption in mice results in osteopetrosis, absence of osteoclasts, and defects in T/B lymphocyte differentiation and mammary gland development.
Two alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.