Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), PE-Cyanine7, eBioscience
인간 및 영장류 CD11b 검출용 단클론 항체로, PE-Cyanine7 형광 표지되어 흐름세포분석(Flow Cytometry)에 최적화됨. ICRF44 클론 기반으로 높은 특이성과 재현성을 제공하며, 광민감성 주의 필요. 연구용으로 세포 표면 접착 분자 분석에 적합.
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Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), PE-Cyanine7, eBioscience™
Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (1 µg)/test
- View 40 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human, Rhesus monkey, Baboon, Chimpanzee |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICRF44 |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1582273 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395, 496, 563, 615, 661, 737, 805
- Brilliant Violet 421, 480, 605, 650, 711, 786
- eFluor 506
- FITC
- NovaFluor Blue / Red / Violet / Yellow Series
- PE, PE-Cyanine5, PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436, 600, 645, 702, 780
- Request custom conjugation
Product Specific Information
The ICRF44 monoclonal antibody reacts with human CD11b, a 165 kDa adhesion molecule associated with integrin beta2 (CD18). CD11b is expressed on monocytes, granulocytes, activated lymphocytes, and a subset of NK cells. It serves as a receptor for ICAM family members (CD54, CD102, CD50) and iC3b, mediating cell-cell and cell-matrix interactions.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and tested on normal human peripheral blood cells; use at 5 µL (1 µg) per test (100 µL final volume).
- Light Sensitivity: Protect vial and samples from light.
- Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-822-49) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days at 4°C in the dark.
- Excitation/Emission: 488–561 nm / 775 nm; compatible with Blue, Green, and Yellow-Green lasers.
- Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that forms a heterodimer with integrin beta-2 (CD18), known as Mac-1 or CR3. It is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, NK cells, dendritic cells, and microglia. CD11b/CD18 acts as a receptor for ICAMs, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X, playing a key role in immune cell adhesion and migration.
CD11b expression varies across tissues—high in bone marrow cells and peritoneal macrophages, low in thymocytes. It serves as a microglial marker and is associated with systemic lupus erythematosus and ITGAM-related autoimmune susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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