Thermo Fisher Scientific IL2RG Chimeric Recombinant Rabbit Monoclonal Antibody (3E12)
IL2RG 단백질을 인식하는 키메릭 재조합 토끼 단클론 항체로, 마우스 시료에 반응합니다. ICC/IF, Flow Cytometry, IP, Inhibition Assay에 사용 가능합니다. Protein A로 정제된 액상 항체이며, 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3E12 |
| Immunogen | Lewis rats immunised with transfected rat myeloma cell line YB2/0 expressing murine cytoplasmic-tailless IL-2R common gamma-chain (YB2/0-myt) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074662 |
Product Specific Information
Specificity:
This conformation-dependent antibody binds to the murine common gamma-chain, shared by the IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptor complexes. It recognises an epitope located in a membrane-proximal portion of the common gamma-chain, near Arg-197 of domain 2.
This antibody does not cross-react with COS7 cells transfected with rat common gamma-chain cDNA.
Target Information
IL2RG (Interleukin 2 Receptor Gamma):
IL2RG is an important signaling component of many interleukin receptors, including those of interleukin-2, -4, -7, and -21, and is thus referred to as the common gamma chain.
Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID) as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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