Thermo Fisher Scientific Phospho-TrkC (Tyr705) Polyclonal Antibody
TrkC 단백질의 Tyr705 인산화 형태를 특이적으로 검출하는 폴리클로날 항체로, Western blot 및 IHC(Paraffin) 분석에 적합합니다. Rabbit IgG 형식이며, 고순도의 액상 형태로 제공됩니다. 신경계 관련 연구용으로 최적화된 항체입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NTRK3 (Accession Q16288), corresponding to amino acid residues around phosphorylated Tyr705 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818495 |
Product Specific Information
Antibody detects endogenous levels of TrkC only when phosphorylated at Tyr705.
Target Information
NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors include SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in nervous tissue. Isoform B is expressed in a relatively large amount in the adult brain compared to the fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains two immunoglobulin-like C2-type domains and two leucine-rich (LRR) repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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