Thermo Fisher Scientific Phospho-p27 Kip1 (Thr157) Polyclonal Antibody
Phospho-p27 Kip1 (Thr157) 특이적 인식 항체로, 세포주기 조절 단백질의 인산화 상태 분석에 적합. WB, IHC, ICC/IF 등에 사용 가능. Rabbit Polyclonal 형태로 높은 특이성과 재현성을 제공. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDKN1B (Accession P46527), corresponding to amino acid residues around phosphorylated Thr157 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818499 |
Product Specific Information
Antibody detects endogenous levels of p27 Kip1 only when phosphorylated at Thr157.
Target Information
p27 Kip1 functions as a negative regulator of G1 phase progression and may mediate TGFβ-induced G1 arrest. It is a key regulator of cell cycle progression and inhibits cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 interacts with cyclin D-CDK4 complexes, influencing their assembly and activation depending on its phosphorylation state. The protein (~27 kDa) undergoes CDK-dependent phosphorylation and ubiquitination by SCF complexes, facilitating transition from quiescence to proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-99566_p27Kip1_P46527-1_Rabbit.svg, PA5-99566_p27Kip1_P46527-1_Rabbit_PDP.jpeg)
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