Thermo Fisher Scientific beta synuclein Polyclonal Antibody
Human, Mouse, Rat에 반응하는 폴리클로날 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. KLH 결합 합성 펩타이드(aa 21-120)를 면역원으로 사용하였으며, Protein A로 정제된 1 mg/mL 액상 제품입니다. -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human beta Synuclein, amino acids 21–120 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates, they are encoded by three different genes. Synucleins have been implicated in major diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and breast cancer.
- In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid.
- In PD, alpha synuclein accumulates in Lewy bodies, and certain alleles are linked to familial PD cases.
- In breast cancer, increased expression of gamma synuclein correlates with disease progression.
Synucleins also appear to play a role in membrane plasticity in developing song control systems of songbirds.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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