Thermo Fisher Scientific Periostin Polyclonal Antibody
Human Periostin을 인식하는 Rabbit Polyclonal Antibody로 다양한 응용(WB, IHC, ICC, ELISA)에 사용 가능. Recombinant Human Periostin을 면역원으로 제작. 보존제가 없는 액상 형태로 제공되며, 장기보관 시 -20°C 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Periostin/POSTN/OSF-2 Protein (Met1–Gln781) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788182 |
Product Specific Information
- This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.
- This antibody has specificity for Human Periostin/POSTN/OSF-2.
Target Information
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally isolated as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins.
In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading, and attachment.
Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGFβ1).
Periostin contains a typical signal sequence, a cysteine-rich domain, a fourfold repeated domain homologous to the insect protein fasciclin, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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