Thermo Fisher Scientific TCR V alpha 2 Monoclonal Antibody (F1)
인간 및 비인간 영장류 반응성을 가진 TCR V alpha 2 단클론 항체(F1). Western blot, IHC, Flow cytometry 등 다양한 응용 가능. Protein A로 정제된 액상 항체로, PBS/BSA buffer에 보관. 연구용으로 적합하며 -20°C에서 안정적으로 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 8 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1–2 µg/test | View 3 publications |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F1 |
| Immunogen | Human TCR V alpha-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.5% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_417088 |
Additional Formats
Target Information
T cell receptors (TCRs) are critical for distinguishing foreign from self-peptides presented by MHC class II molecules, enabling effective adaptive immune responses. Recognition of self-peptides by TCRs is linked to autoimmune diseases, while mutant self-peptides have been associated with tumors. Superantigen engagement of TCRs can lead to toxic shock syndrome. Autoantibodies to TCR V beta segments have been identified in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially serving as a compensatory immune mechanism. Most human T cells express TCR alpha-beta with CD4 or CD8, while a small subset lacks both (double negative, DN). Increased DN T cells are found in certain autoimmune and immunodeficiency disorders. Gamma-delta T cells, mainly in epithelial tissues, exhibit limited diversity and distinct antigen recognition, with subsets showing antitumor and immunoregulatory activity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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