Thermo Fisher Scientific TCR V alpha 2 Monoclonal Antibody (F1)

Applications and Tested Dilution

Product Specifications

Additional Formats

• FITC Conjugate
• Request custom conjugation

Target Information

T cell receptors (TCRs) are critical for distinguishing foreign from self-peptides presented by MHC class II molecules, enabling effective adaptive immune responses. Recognition of self-peptides by TCRs is linked to autoimmune diseases, while mutant self-peptides have been associated with tumors. Superantigen engagement of TCRs can lead to toxic shock syndrome. Autoantibodies to TCR V beta segments have been identified in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially serving as a compensatory immune mechanism. Most human T cells express TCR alpha-beta with CD4 or CD8, while a small subset lacks both (double negative, DN). Increased DN T cells are found in certain autoimmune and immunodeficiency disorders. Gamma-delta T cells, mainly in epithelial tissues, exhibit limited diversity and distinct antigen recognition, with subsets showing antitumor and immunoregulatory activity.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.