Thermo Fisher Scientific Parkin Chimeric Recombinant Mouse Monoclonal Antibody (21H24L9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG

Expression System

ExpiCHO

Class

Recombinant Monoclonal

Type

Antibody

Clone

21H24L9

Immunogen

Protein corresponding to human Parkin [aa1-aa465] if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Parkin,uniProtId:O60260-1,ncbiNodeId:9606,antigenRange:1-465,antigenLength:465,antigenImageFileName:702785M_Parkin_O60260-1_House_mouse.svg,antigenImageFileNamePDP:702785M_Parkin_O60260-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

View additional formats

• HRP
• Request custom conjugation

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

This antibody has Rabbit Variable heavy and light chains, and Mouse constant domains. It recognizes human, mouse and Rat Parkin protein. This chimeric antibody is recognized by anti-mouse secondary antibodies and has no cross reactivity to anti-rabbit secondary antibodies.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Target Information

The precise function of Parkin gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.