Thermo Fisher Scientific IL-22 Monoclonal Antibody (22URTI), PE, eBioscience
인간 IL-22에 특이적인 마우스 단클론 항체로, PE 형광 표지되어 Flow Cytometry 및 ICC/IF 분석에 적합합니다. Th17 및 NK 세포에서 분비되는 IL-22 검출에 사용되며, 488–561 nm 파장에서 효율적 형광 신호를 제공합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific IL-22 Monoclonal Antibody (22URTI), PE, eBioscience™
Applications
Immunocytochemistry (ICC/IF)
Tested Dilution: –
Publications: View 1 publicationFlow Cytometry (Flow)
Tested Dilution: 5 µL (0.06 µg)/test
Publications: View 20 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 22URTI |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1834464 |
Available Formats
- Brilliant UV 395
- Brilliant UV 563
- Brilliant UV 661
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 421
- Brilliant Violet 605
- eFluor 450
- eFluor 660
- FITC
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation available
Product Specific Information
The 22URTI monoclonal antibody reacts with human interleukin (IL)-22, a 20 kDa cytokine of the IL-10 family secreted mainly by Th17 and NK cells.
In vitro, IL-22 expression is induced more strongly by IL-23 than by IL-6 or TGF-β, suggesting secretion by differentiated Th17 cells.
The IL-22 receptor is a heterodimer of IL-10R2 and IL-22R1.
Applications Reported:
Used for intracellular staining and flow cytometric analysis.
Applications Tested:
Pre-titrated and tested for intracellular staining of restimulated, Th17-polarized CD4+ human peripheral blood cells.
Recommended usage: 5 µL (0.01 µg) per test (100 µL final volume).
Cell number range: 10⁵–10⁸ cells/test.
Optical Properties:
- Excitation: 488–561 nm
- Emission: 578 nm
- Compatible Lasers: Blue, Green, Yellow-Green
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL-22 (IL-10-related T-cell derived inducible factor) is an alpha-helical cytokine belonging to the IFN-IL-10 family, including IL-19, IL-20, IL-24, IL-26, IL-28, and IL-29.
Produced mainly by activated T cells and NK cells, IL-22 interacts with the receptor complex IL-22R1/IL-10R2, activating JAK-STAT signaling.
It primarily targets nonimmune cells such as epithelial cells, hepatocytes, and keratinocytes, regulating innate immunity and wound healing.
IL-22 is co-expressed with IL-17A and IL-17F in Th17 cells and contributes to antimicrobial protein induction and keratinocyte mobility.
Highly expressed during chronic inflammation, IL-22 plays a critical role in host defense and tissue repair.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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