Thermo Fisher Scientific MYOM1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total MYOM1.

Target Information

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2).
Myomesin 1, like myomesin 2, titin, and other myofibrillar proteins, contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains.
Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region.
The head structure formed by these two proteins on one end of the titin string extends into the center of the M band.
The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins.
Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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