Thermo Fisher Scientific MYOZ2 Polyclonal Antibody

Thermo Fisher Scientific MYOZ2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:2,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total Myozenin2.

Target Information

The calcineurin-binding protein Myozenin 2, also known as calsarcin-1, is a member of the calsarcin protein family. Calcineurin is a calcium- and calmodulin-dependent protein phosphatase involved in controlling slow fiber gene expression in skeletal muscle and cardiac muscle hypertrophy.
Calsarcins are sarcomeric proteins that couple calcineurin and muscle activity. In cardiac and skeletal muscle cells, Myozenin 2 binds calcineurin to α-actinin at the Z-line of the sarcomere.
During embryogenesis, Myozenin 1 and 2 are expressed in developing muscle. The Myozenin 2 gene maps to chromosome 4q and is expressed specifically in adult cardiac and slow-twitch skeletal muscle, while Myozenin 1 is only detected in fast skeletal muscle.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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