Thermo Fisher Scientific TACR3 Polyclonal Antibody
Rat NK-3 receptor 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 합성 펩타이드를 면역원으로 제작. 동결건조 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal residues A(434) S T T S S F I S S P Y T S V D E Y S(452) of rat NK-3 receptor protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2200909 |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution, store aliquots at -20°C for higher stability, or at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
Tachykinins are small peptide neurotransmitters including substance P, neurokinin A, and neurokinin B, acting on three distinct G-protein coupled receptors. The NK-3 receptor (NK3R) has the highest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Upon ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely leading to vasopressin and oxytocin release. NK3R may also be involved in learning and memory, as knockout mice exhibit cognitive deficits. It is suggested to play a role in vagal afferent neuron regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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