Thermo Fisher Scientific Phospho-ATP Citrate Lyase (Ser455) Polyclonal Antibody
ATP Citrate Lyase의 Ser455 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 검증됨. 비결합(Unconjugated) 형태의 액상 시약으로, -20°C에서 보관. 세포 내 Acetyl-CoA 합성 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human ATP-Citrate Lyase around the phosphorylation site of Ser455 (T-A-SP-F-S) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554957 |
Target Information
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with the hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, is involved in several biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may play a role in acetylcholine biosynthesis. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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